Psori Silk in Mild to Moderate Psoriasis: Randomized Phase I-II Study

 

Abstract

Objectives: To assess efficacy and safety of Psori Silk in mild to moderate plaque psoriasis.

Material and Methods: Randomized double blind Psori Silk versus vehicle, 12 weeks treatment and 4 weeks follow up study. The primary endpoint was Modified PASI 50 at week 12, while the secondary endpoint included life quality assessment by DLQI.

Results: The Psori Silk group consisted of 23 patients with 34 lesions treated versus 22 and 36 in the vehicle group, respectively.

Modified PASI 50 seen in 59% versus 22.7% of patients in the active and the vehicle group, respectively (p< 0.001). Mean 33% DLQI improvement was observed in 65.2 versus 27.2% (p< 0.001) of active medicine and vehicle group patients, respectively. Mild and temporary discomfort at the application site was observed in 39 and 23% of the active medicine and vehicle group patients, respectively.

Conclusions: Psori Silk appear to be effective and safe treatment for mild to moderate plaque psoriasis. Keywords: plaque psoriasis; natural medicine; Psori Silk; Modified PASI 50; DLQI.

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Sickle Cell Anemia Versus Sickle Cell Diseases in Adults

 

Abstract

Background: We tried to understand prevalence and clinical severity of sickle cell anemia (SCA) alone or sickle cell diseases (SCD) with associated alpha- or beta-thalassemias in adults.

Methods: All adults with the SCA or SCD were studied.

Results: The study included 441 patients (215 females). The prevalence of SCA was significantly lower than the SCD in adults (29.0% versus 70.9%, p<0.001). The mean age and female ratio were similar in the SCA and SCD groups (31.2 versus 30.5 years and 52.3% versus 47.2%, p>0.05 for both, respectively). The mean body mass index was similar in both groups, too (21.5 versus 21.7 kg/m2, p>0.05, respectively). On the other hand, the total bilirubin value of the plasma was higher in the SCA, significantly (5.7 versus 4.4 mg/dL, p= 0.000). Whereas the total number of transfused units of red blood cells in their lives was similar in the SCA and SCD groups (43.6 versus 37.1 units, p>0.05, respectively).

Conclusion: The SCA alone and SCD are severe inflammatory processes on vascular endothelium particularly at the capillary level and terminate with an accelerated atherosclerosis and end-organ failures in early years of life. The relatively suppressed hemoglobin S synthesis in the SCD secondary to the associated thalassemia’s may decrease sickle cell-induced chronic endothelial damage, inflammation, edema, fibrosis, and end-organ failures. The lower prevalence of the SCA in adults and the higher total bilirubin value of the plasma in them may indicate the relative severity of hemolytic process, vascular endothelial inflammation, and hepatic involvement in the SCA.

Read more about this article: https://lupinepublishers.com/complementary-alternative-medicine-journal/fulltext/sickle-cell-anemia-versus-sickle-cell-diseases-in-adults.ID.000163.php

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