Psori Silk in Mild to Moderate Psoriasis: Randomized Phase I-II Study

 

Abstract

Objectives: To assess efficacy and safety of Psori Silk in mild to moderate plaque psoriasis.

Material and Methods: Randomized double blind Psori Silk versus vehicle, 12 weeks treatment and 4 weeks follow up study. The primary endpoint was Modified PASI 50 at week 12, while the secondary endpoint included life quality assessment by DLQI.

Results: The Psori Silk group consisted of 23 patients with 34 lesions treated versus 22 and 36 in the vehicle group, respectively.

Modified PASI 50 seen in 59% versus 22.7% of patients in the active and the vehicle group, respectively (p< 0.001). Mean 33% DLQI improvement was observed in 65.2 versus 27.2% (p< 0.001) of active medicine and vehicle group patients, respectively. Mild and temporary discomfort at the application site was observed in 39 and 23% of the active medicine and vehicle group patients, respectively.

Conclusions: Psori Silk appear to be effective and safe treatment for mild to moderate plaque psoriasis. Keywords: plaque psoriasis; natural medicine; Psori Silk; Modified PASI 50; DLQI.

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